Carney complex

Ann Thorac Surg. 2006 Jul;82(1):320-2. doi: 10.1016/j.athoracsur.2005.07.099.

Abstract

We report an illustrated case of a 61-year-old woman with multiple atrial myxomas and cutaneous hyperpigmentation as part of the Carney complex. The case is notable for an unusually late presentation in life and a strong family history of atrial myxomas and sudden death. The importance of regular life-long echocardiographic screening and surveillance in all family members of affected cases is emphasized.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Breast Neoplasms / genetics
  • Breast Neoplasms / surgery
  • Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
  • Cyclic AMP-Dependent Protein Kinases / genetics*
  • DNA Mutational Analysis
  • Death, Sudden, Cardiac
  • Female
  • Fibroadenoma / genetics
  • Fibroadenoma / surgery
  • Genes, Dominant
  • Genetic Testing
  • Heart Atria / diagnostic imaging
  • Heart Atria / surgery
  • Heart Neoplasms / diagnostic imaging
  • Heart Neoplasms / epidemiology
  • Heart Neoplasms / genetics*
  • Heart Neoplasms / surgery
  • Humans
  • Hyperpigmentation / epidemiology
  • Hyperpigmentation / genetics*
  • Lentigo / genetics
  • Male
  • Middle Aged
  • Myxoma / diagnostic imaging
  • Myxoma / epidemiology
  • Myxoma / genetics*
  • Myxoma / surgery
  • Neoplasms, Multiple Primary / diagnostic imaging
  • Neoplasms, Multiple Primary / epidemiology
  • Neoplasms, Multiple Primary / genetics*
  • Neoplasms, Multiple Primary / surgery
  • Neoplastic Syndromes, Hereditary / diagnosis
  • Neoplastic Syndromes, Hereditary / epidemiology
  • Neoplastic Syndromes, Hereditary / genetics*
  • Nevus, Pigmented / genetics
  • Pedigree
  • Ultrasonography

Substances

  • Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
  • PRKAR1A protein, human
  • Cyclic AMP-Dependent Protein Kinases