Mass spectrometric identification and characterization of a new long-term metabolite of metandienone in human urine

Rapid Commun Mass Spectrom. 2006;20(15):2252-8. doi: 10.1002/rcm.2587.

Abstract

Anabolic-androgenic steroids are some of the most frequently detected drugs in amateur and professional sports. Doping control laboratories have developed numerous assays enabling the determination of administered drugs and/or their metabolic products that allow retrospectives with respect to pharmacokinetics and excretion profiles of steroids and their metabolites. A new metabolite generated from metandienone has been identified as 18-nor-17beta-hydroxymethyl,17alpha-methyl-androst-1,4,13-trien-3-one in excretion study urine samples providing a valuable tool for the long-term detection of metandienone abuse by athletes in sports drug testing. The metabolite was characterized using gas chromatography/(tandem) mass spectrometry, liquid chromatography/tandem mass spectrometry and liquid chromatography/high-resolution/high-accuracy (tandem) mass spectrometry by characteristic fragmentation patterns representing the intact 3-keto-1,4-diene structure in combination with typical product ions substantiating the proposed C/D-ring structure of the steroid metabolite. In addition, structure confirmation was obtained by the analysis of excretion study urine specimens obtained after administration of 17-CD(3)-labeled metandienone providing the deuterated analogue to the newly identified metabolite. 18-Nor-17beta-hydroxymethyl,17alpha-methyl-androst-1,4,13-trien-3-one was determined in metandienone administration study urine specimens up to 19 days after application of a single dose of 5 mg, hence providing an extended detection period compared with commonly employed strategies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chromatography, Gas / methods*
  • Chromatography, Liquid / methods*
  • Humans
  • Male
  • Mass Spectrometry / methods*
  • Metabolic Clearance Rate
  • Methandrostenolone / chemistry*
  • Methandrostenolone / urine*
  • Middle Aged
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Specimen Handling / methods
  • Substance Abuse Detection / methods*
  • Urinalysis / methods*

Substances

  • Methandrostenolone