Abstract
Background:
To determine the etiologic agent of an atypical pneumonia human case admitted to Xiangtan City hospital, Hunan Province in Oct. 2005.
Methods:
The patient's respiratory tract samples and serum were collected. Throat swabs were tested by microneutralization and hemagglutination-inhibition assays.
Results:
The results of nucleic acid detection of all respiratory samples were negative and virus isolation was also negative. The H5-specific antibodies of convalescence showed a 4-fold greater rise than acute phase.
Conclusion:
The atypical pneumonias case was confirmed as the first human case of avian influenza A (H5N1) infection in the mainland of China.
Publication types
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Case Reports
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Viral / blood
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Cell Line
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Chick Embryo
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Child
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China
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Clinical Laboratory Techniques
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Hemagglutination Inhibition Tests
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Hemagglutinin Glycoproteins, Influenza Virus / genetics
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Hemagglutinin Glycoproteins, Influenza Virus / immunology
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Humans
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Influenza A Virus, H5N1 Subtype / genetics
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Influenza A Virus, H5N1 Subtype / immunology
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Influenza A Virus, H5N1 Subtype / isolation & purification*
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Influenza, Human / diagnosis*
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Influenza, Human / virology
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Male
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Neutralization Tests
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Pneumonia, Viral / diagnosis
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Pneumonia, Viral / virology
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Reagent Kits, Diagnostic
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Reverse Transcriptase Polymerase Chain Reaction
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Sequence Analysis, DNA
Substances
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Antibodies, Viral
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Hemagglutinin Glycoproteins, Influenza Virus
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Reagent Kits, Diagnostic