Diversity synthesis using the complimentary reactivity of rhodium(II)- and palladium(II)-catalyzed reactions

J Org Chem. 2006 Jul 21;71(15):5594-8. doi: 10.1021/jo060636u.

Abstract

Rhodium(II)-catalyzed reactions of aryldiazoacetates can be conducted in the presence of iodide, triflate, organoboron, and organostannane functionality, resulting in the formation of a variety of cyclopropanes or C-H insertion products with high stereoselectivity. The combination of the rhodium(II)-catalyzed reaction with a subsequent palladium(II)-catalyzed Suzuki coupling offers a novel strategy for diversity synthesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Catalysis
  • Cycloheptanes / chemical synthesis*
  • Hydrocarbons, Halogenated / chemical synthesis*
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis*
  • Palladium / chemistry*
  • Rhodium / chemistry*

Substances

  • Cycloheptanes
  • Hydrocarbons, Halogenated
  • Organometallic Compounds
  • Palladium
  • Rhodium