Abstract
How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and an siRNA targeting the insulin-like growth factor-1 (IGF-1) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3-kinase (PI3k)-Cdc42 pathway by the IGF-1 receptor, but not by the TrkA or TrkB receptors.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Polarity*
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Cells, Cultured
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Hippocampus / cytology*
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Neurons / cytology*
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Neurons / metabolism
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Phosphatidylinositol 3-Kinases / metabolism
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RNA, Small Interfering / genetics
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RNA, Small Interfering / metabolism
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Rats
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Receptor, IGF Type 1 / genetics
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Receptor, IGF Type 1 / metabolism*
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Receptor, trkA / metabolism
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Receptor, trkB / metabolism
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cdc42 GTP-Binding Protein / metabolism
Substances
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RNA, Small Interfering
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Phosphatidylinositol 3-Kinases
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Receptor, IGF Type 1
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Receptor, trkA
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Receptor, trkB
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cdc42 GTP-Binding Protein