[Determination of the frequency of the A2m (2) allele of immunoglobin A in the Tunisian population by RFLP analysis]

Rev Fr Transfus Hemobiol. 1991 Dec;34(6):441-7. doi: 10.1016/s1140-4639(05)80138-8.
[Article in French]

Abstract

The human IgA2 subclass has two allotypes A2m(1) and A2m (2). Using the RFLP technique, we determined the A2m(2) frequency in a sample of 29 tunisian individuals. In accordance with Lefranc and all. [6], the presence of a polymorphic EcoRI site of the A2m(2) allele was confirmed in our RFLP study whereas no BamHI nor HindIII polymorphisms were shown. Among the 29 cases studies, 11 were heterozygous A2m2-1, 17 homozygous A2m1-1 and 1 homozygous A2m2-2. The A2m2 allele frequency in the Tunisian population (0,22) is intermediate between the European frequency and the African one.

Publication types

  • English Abstract

MeSH terms

  • Complement Factor B / genetics
  • Gene Frequency
  • Genes, Immunoglobulin*
  • Humans
  • Immunoglobulin A / genetics*
  • Immunoglobulin Allotypes / genetics*
  • Polymorphism, Restriction Fragment Length
  • Tunisia / ethnology

Substances

  • Immunoglobulin A
  • Immunoglobulin Allotypes
  • Complement Factor B