Inhibition of JNK increases survival of transplanted dopamine neurons in Parkinsonian rats

Cell Death Differ. 2007 Feb;14(2):381-3. doi: 10.1038/sj.cdd.4402010. Epub 2006 Jul 21.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthracenes / pharmacology
  • Cell Survival / drug effects
  • Disease Models, Animal
  • Dopamine / metabolism*
  • Dose-Response Relationship, Drug
  • Graft Survival / drug effects
  • JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors*
  • Mesencephalon / cytology
  • Mesencephalon / drug effects
  • Neurons / cytology
  • Neurons / drug effects
  • Neurons / enzymology*
  • Neurons / transplantation*
  • Parkinson Disease / enzymology*
  • Parkinson Disease / pathology*
  • Rats
  • Tyrosine 3-Monooxygenase / metabolism

Substances

  • Anthracenes
  • pyrazolanthrone
  • Tyrosine 3-Monooxygenase
  • JNK Mitogen-Activated Protein Kinases
  • Dopamine