Percutaneous coronary intervention for the treatment of aorto-ostial in-stent restenosis poses unique technical challenges not offered by other lesion subtypes. These difficulties are further enhanced when encountered with a case of deformed stent struts preventing coaxial guiding catheter engagement and introduction of guidewire through the true stent lumen. In this report, we describe a method of stenting through stent struts side-strut stenting for treating aorto-ostial in-stent restenosis associated with deformed stent struts resulting in good long-term outcome.