Cytotoxic activities of chemical constituents from Mesua daphnifolia

Trop Biomed. 2005 Dec;22(2):99-102.

Abstract

Detail chemical investigations on the stem bark of Mesua daphnifolia gave three triterpenoids and four xanthones. They are friedelin (1), friedelan-1,3-dione (2), lup-20(29)- en-3ss-ol (3), cudraxanthone G (4), ananixanthone (5), 1,3,5-trihydroxy-4-methoxyxanthone (6) and euxanthone (7). These chemical constituents were tested in vitro for their cytotoxic activities against four cell lines, MDA-MB-231 (human estrogen receptor negative breast cancer), HeLa (cervical carcinoma), CEM-SS (T-lymphoblastic leukemia) and CaOV3 (human ovarian cancer). Compound 4 showed a broad spectrum of activity against the MDA-MB-231, HeLa and CEM-SS cell lines with IC5 0 values of 1.3, 4.0 and 6.7 microg/ml respectively. Meanwhile, the other compounds 1, 2, 3, 5, 6 and 7 gave only selective activities against the cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / toxicity*
  • Cell Line, Tumor / drug effects
  • Clusiaceae / chemistry*
  • Clusiaceae / classification
  • Drug Screening Assays, Antitumor
  • HeLa Cells / drug effects
  • Humans
  • Malaysia
  • Plant Bark / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / toxicity*
  • Structure-Activity Relationship
  • Terpenes / chemistry
  • Terpenes / toxicity*
  • Xanthones / chemistry
  • Xanthones / toxicity*

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Terpenes
  • Xanthones
  • euxanthone