Abstract
HepG2 cells were treated with Helicobacter pylori (Hp) at different concentrations and the cell killing and apoptosis of the cells were measured with MTT assay and Hoechst 33258 staining technique. The results showed that with the increment of cagA (+) Hp concentration, HepG2 cell killing and apoptosis rate increased in a concentration-dependent manner, but cagA (-) Hp did not significantly impacted on the proliferation and apoptosis of HepG2.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Bacterial / metabolism
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Apoptosis / physiology*
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Bacterial Proteins / metabolism
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Carcinoma, Hepatocellular / microbiology
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Carcinoma, Hepatocellular / pathology
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Cell Line, Tumor
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Cell Proliferation*
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Cell Survival / physiology
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Helicobacter pylori / immunology
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Helicobacter pylori / physiology*
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Humans
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Liver Neoplasms / microbiology
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Liver Neoplasms / pathology
Substances
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Antigens, Bacterial
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Bacterial Proteins
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cagA protein, Helicobacter pylori