[Helicobacter pylori induces damage of HepG2 cells in vitro]

Nan Fang Yi Ke Da Xue Xue Bao. 2006 Aug;26(8):1219-21.
[Article in Chinese]

Abstract

HepG2 cells were treated with Helicobacter pylori (Hp) at different concentrations and the cell killing and apoptosis of the cells were measured with MTT assay and Hoechst 33258 staining technique. The results showed that with the increment of cagA (+) Hp concentration, HepG2 cell killing and apoptosis rate increased in a concentration-dependent manner, but cagA (-) Hp did not significantly impacted on the proliferation and apoptosis of HepG2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Bacterial / metabolism
  • Apoptosis / physiology*
  • Bacterial Proteins / metabolism
  • Carcinoma, Hepatocellular / microbiology
  • Carcinoma, Hepatocellular / pathology
  • Cell Line, Tumor
  • Cell Proliferation*
  • Cell Survival / physiology
  • Helicobacter pylori / immunology
  • Helicobacter pylori / physiology*
  • Humans
  • Liver Neoplasms / microbiology
  • Liver Neoplasms / pathology

Substances

  • Antigens, Bacterial
  • Bacterial Proteins
  • cagA protein, Helicobacter pylori