Functional anatomy and interaction of fast and slow visual pathways in macaque monkeys

Cereb Cortex. 2007 Jul;17(7):1561-9. doi: 10.1093/cercor/bhl067. Epub 2006 Sep 1.

Abstract

We measured the timing, areal distribution, and laminar profile of fast, wavelength-insensitive and slower, wavelength-sensitive responses in V1 and extrastriate areas, using laminar current-source density analysis in awake macaque monkeys. There were 3 main findings. 1) We confirmed previously reported significant ventral-dorsal stream latency lags at the level of V4 (V4 mean = 38.7 ms vs. middle temporal mean = 26.9 ms) and inferotemporal cortex (IT mean = 43.4 ms vs. dorsal bank of the superior temporal sulcus mean = 33.9 ms). 2) We found that wavelength-sensitive inputs in areas V1, V4, and IT lagged the wavelength-insensitive responses by significant margins; this lag increased over successive levels of the system. 3) We found that laminar activation profiles in V4 and IT were inconsistent with "feedforward" input through the ascending ventral cortical pathway; the likely alternative input routes include both lateral inputs from the dorsal stream and direct inputs from nonspecific thalamic neurons. These findings support a "Framing" Model of ventral stream visual processing in which rapidly conducted inputs, mediated by one or more accessory pathways, modulate the processing of more slowly conducted feedforward inputs.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Brain Mapping
  • Evoked Potentials, Visual / physiology
  • Macaca fascicularis
  • Male
  • Nerve Net / cytology*
  • Nerve Net / physiology*
  • Neurons, Afferent / cytology*
  • Neurons, Afferent / physiology*
  • Photic Stimulation / methods
  • Reaction Time / physiology*
  • Visual Pathways / cytology*
  • Visual Pathways / physiology*