Preliminary crystallographic analysis of the Fab fragment of an antibody against HIV gp120

J Mol Biol. 1990 Jul 5;214(1):23-4. doi: 10.1016/0022-2836(90)90142-9.

Abstract

Single crystals of the Fab fragment of a murine monoclonal antibody BAT123 (IgG1, kappa) raised against a dominant neutralizing determinant of gp120 of HIV that are suitable for X-ray structural analysis have been obtained. The thick prismatic plate crystals belong to space group P2(1)2(1)2 with unit cell dimensions of a = 177.42 A, b = 37.36 A and c = 73.30 A.

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Epitopes / immunology
  • HIV Antibodies*
  • HIV Envelope Protein gp120 / immunology*
  • Immunoglobulin Fab Fragments
  • Mice
  • Mice, Inbred BALB C
  • X-Ray Diffraction

Substances

  • Antibodies, Monoclonal
  • Epitopes
  • HIV Antibodies
  • HIV Envelope Protein gp120
  • Immunoglobulin Fab Fragments