Successful treatment of acquired amegakaryocytic thrombocytopenia with cyclosporine in adult onset Still's disease

Rheumatol Int. 2007 Jan;27(3):295-8. doi: 10.1007/s00296-006-0202-8. Epub 2006 Sep 7.

Abstract

Acquired amegakaryocytic thrombocytopenia (AAT) is a rare disorder, characterized by severe thrombocytopenia and selective, marked decrease or absence of megakaryocytes in the bone marrow. We describe a 29-year-old female with adult onset Still's disease preceding a diagnosis of AAT and autoimmune hemolytic anemia, which was successfully treated with cyclosporine. This is the first case of AAT in a patient with adult onset Still's disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anemia, Hemolytic, Autoimmune / complications
  • Anemia, Hemolytic, Autoimmune / drug therapy*
  • Antirheumatic Agents / therapeutic use*
  • Cyclosporine / therapeutic use*
  • Female
  • Humans
  • Megakaryocytes / drug effects
  • Platelet Transfusion
  • Still's Disease, Adult-Onset / complications
  • Still's Disease, Adult-Onset / drug therapy*
  • Thrombocytopenia / complications
  • Thrombocytopenia / drug therapy*

Substances

  • Antirheumatic Agents
  • Cyclosporine