Genotoxic activity of halogenated phenylglycine derivatives

Bioorg Med Chem Lett. 2006 Dec 1;16(23):6073-7. doi: 10.1016/j.bmcl.2006.08.111. Epub 2006 Sep 20.

Abstract

The discovery of genotoxic amino acids derived from phenylglycine, and possessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzamidines / chemistry
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • DNA Damage*
  • Glycine / analogs & derivatives
  • Glycine / chemical synthesis
  • Glycine / chemistry*
  • Glycine / toxicity*
  • Halogens / chemistry*
  • Humans
  • Molecular Structure
  • Nitrogen / chemistry
  • Oxygen / chemistry
  • Saccharomyces cerevisiae / drug effects
  • Saccharomyces cerevisiae / genetics
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Benzamidines
  • Halogens
  • benzamidine
  • Nitrogen
  • Oxygen
  • Glycine