The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population

Schizophr Res. 2006 Dec;88(1-3):245-50. doi: 10.1016/j.schres.2006.07.019. Epub 2006 Sep 28.

Abstract

Several lines of evidence suggest that disturbance of myelin-related genes is associated with the etiology of schizophrenia. Recently, the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene and the oligodendrocyte lineage transcription factor 2 (OLIG2) gene were reported to be related to the development of schizophrenia, based on the results of genetic association and microarray studies. In the present study, no significant association with schizophrenia was observed by single-marker or haplotype analysis for 6 tag SNPs of these genes (759 cases, 757 controls). These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2',3'-Cyclic-Nucleotide Phosphodiesterases / genetics*
  • Adult
  • Asian People / genetics*
  • Basic Helix-Loop-Helix Transcription Factors / genetics*
  • Female
  • Genotype
  • Humans
  • Linkage Disequilibrium / genetics
  • Male
  • Middle Aged
  • Myelin Sheath / genetics
  • Nerve Tissue Proteins / genetics*
  • Oligodendrocyte Transcription Factor 2
  • Oligonucleotide Array Sequence Analysis / methods
  • Polymerase Chain Reaction
  • Schizophrenia / ethnology*
  • Schizophrenia / genetics*

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • Nerve Tissue Proteins
  • OLIG2 protein, human
  • Oligodendrocyte Transcription Factor 2
  • 2',3'-Cyclic-Nucleotide Phosphodiesterases