Abstract
Recent work has identified a role for metabotropic glutamate receptor subtype 5 (mGlu(5)) in the discriminative stimulus properties of investigator-administered ethanol. The purpose of this study was to determine if mGlu(5) receptors modulate the discriminative stimulus properties of self-administered ethanol. Results show that the mGlu(5) receptor antagonist 6-Methyl-2-(phenylethynyl)pyridine (MPEP; 10 mg/kg) inhibited the discriminative stimulus properties of consumed ethanol during a self-administration test session. Further, 10 mg/kg MPEP increased and 1 mg/kg MPEP decreased the amount of self-administered ethanol required to produce full substitution. These results indicate that mGlu(5) receptors are involved in the expression of the discriminative stimulus properties of self-administered ethanol.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohol Drinking / metabolism*
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Alcohol Drinking / psychology
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Animals
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Behavior, Animal / drug effects*
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Central Nervous System Depressants / administration & dosage
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Central Nervous System Depressants / pharmacology*
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Conditioning, Operant / drug effects
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Discrimination Learning / drug effects*
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Dose-Response Relationship, Drug
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Ethanol / administration & dosage
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Ethanol / pharmacology*
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Excitatory Amino Acid Antagonists / pharmacology
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Male
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Pyridines / pharmacology
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Rats
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Rats, Long-Evans
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate / drug effects*
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Receptors, Metabotropic Glutamate / metabolism
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Self Administration
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Time Factors
Substances
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Central Nervous System Depressants
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Excitatory Amino Acid Antagonists
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Pyridines
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate
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Ethanol
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6-methyl-2-(phenylethynyl)pyridine