Human artificial chromosomes: potential applications and clinical considerations

Joydeep Basu; Huntington F Willard

doi:10.1016/j.pcl.2006.08.013

Human artificial chromosomes: potential applications and clinical considerations

Pediatr Clin North Am. 2006 Oct;53(5):843-53, viii. doi: 10.1016/j.pcl.2006.08.013.

Authors

Joydeep Basu¹, Huntington F Willard

Affiliation

¹ Institute for Genome Sciences & Policy, Duke University, 101 Science Drive, Durham, NC 27708, USA. basu0005@mc.duke.edu

PMID: 17027613
DOI: 10.1016/j.pcl.2006.08.013

Abstract

Human artificial chromosomes demonstrate promise as a novel class of nonintegrative gene therapy vectors. The authors outline current developments in human artificial chromosome technology and examine their potential for clinical application.

Publication types

Review

MeSH terms

Chromosomes, Artificial, Human*
Gene Expression
Gene Transfer Techniques
Genetic Engineering
Genetic Markers
Genetic Therapy / methods*
Genetic Vectors*
Humans

Substances

Genetic Markers