Sexually victimized individuals often report chronic attempts to avoid unpleasant internal experiences (e.g., thoughts, emotions, memories) as a means of affect regulation. The aim of this study was to expand upon previous findings by examining the relationships among negative mood, thought suppression, and posttraumatic stress disorder (PTSD) in a sample of adult women with a history of sexual assault after age 14 and assault-related intrusions in the past week. Chronic thought suppression partially mediated the relationship between negative mood and PTSD symptom severity after covarying the use of worry to control unpleasant thoughts. Findings extend previous studies and suggest that chronic thought suppression may help explain the link between negative mood and PTSD.