Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity

Bioorg Med Chem Lett. 2007 Jan 15;17(2):390-3. doi: 10.1016/j.bmcl.2006.10.039. Epub 2006 Oct 19.

Abstract

A novel class of inhibitors of the hepatitis C virus [substituted 2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridines] is described. Introduction of a fluorine in position 2 of the 2-phenyl substituent of the lead anti-pestivirus compound 1 (5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine) resulted in an analogue with selective activity against HCV in the subgenomic replicon system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology*
  • Cytopathogenic Effect, Viral / drug effects
  • Diarrhea Viruses, Bovine Viral / drug effects
  • Drug Design
  • Drug Evaluation, Preclinical
  • Hepacivirus / drug effects*
  • Humans
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Pestivirus / drug effects*
  • Pyridines / chemical synthesis*
  • Pyridines / pharmacology*
  • Replicon
  • Structure-Activity Relationship

Substances

  • Antiviral Agents
  • Imidazoles
  • Pyridines