Abstract
Staphylococcus aureus peptidoglycan (PG) is completely resistant to the hydrolytic activity of lysozyme. Here we show that modifications in PG by O acetylation, wall teichoic acid, and a high degree of cross-linking contribute to this resistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylation / drug effects
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Cell Wall / chemistry
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Drug Resistance, Bacterial
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Hydrolysis / drug effects
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Muramidase / metabolism
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Muramidase / pharmacology*
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Peptidoglycan / isolation & purification
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Peptidoglycan / metabolism
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Staphylococcus aureus / chemistry
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Staphylococcus aureus / drug effects*
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Teichoic Acids / chemistry
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Teichoic Acids / metabolism*
Substances
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Peptidoglycan
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Teichoic Acids
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Muramidase