Progression from impaired fasting glucose and impaired glucose tolerance to diabetes in a high-risk screening programme in general practice: the ADDITION Study, Denmark

Diabetologia. 2007 Feb;50(2):293-7. doi: 10.1007/s00125-006-0530-y. Epub 2006 Dec 2.

Abstract

Aims/hypothesis: To estimate the 1-year progression rates from both IFG and IGT to diabetes in individuals identified in a pragmatic diabetes screening programme in general practice (the ADDITION Study, Denmark [Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care]).

Methods: Persons aged 40-69 years were screened for type 2 diabetes based on a high-risk, stepwise strategy. At baseline, anthropometric measurements, blood samples and questionnaire data were collected. A total of 1,160 persons had IFG or IGT at baseline: 811 (70%) accepted re-examination after 1 year. Glucose tolerance classification was based on the 1999 WHO definition. At follow-up, diabetes was based on one diabetic glucose value of fasting blood glucose or 2-h blood glucose.

Results: At baseline, 308 persons had IFG and 503 had IGT. The incidence of diabetes was 17.6 and 18.8 per 100 person-years in the two groups, respectively.

Conclusions/interpretation: IFG and IGT identified in general practice during a stepwise, high-risk screening programme for type 2 diabetes have high 1-year progression rates to diabetes. Consequently, intensive follow-up and intervention strategies are recommended for these high-risk individuals.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Blood Glucose / metabolism
  • Denmark / epidemiology
  • Diabetes Mellitus / epidemiology*
  • Diabetes Mellitus / genetics
  • Disease Progression
  • Family Practice / statistics & numerical data
  • Glucose Intolerance / epidemiology*
  • Glucose Intolerance / physiopathology*
  • Humans
  • Mass Screening
  • Middle Aged
  • Risk Factors

Substances

  • Blood Glucose