MPO-ANCA-positive Wegener's granulomatosis presenting with hypertrophic cranial pachymeningitis: case report and review of the literature

Mitsuteru Akahoshi; Goichi Yoshimoto; Hitoshi Nakashima; Katsuhisa Miyake; Yasushi Inoue; Yosuke Tanaka; Hiroshi Tsukamoto; Takahiko Horiuchi; Takeshi Otsuka; Mine Harada

doi:10.1007/s10165-004-0288-3

MPO-ANCA-positive Wegener's granulomatosis presenting with hypertrophic cranial pachymeningitis: case report and review of the literature

Mod Rheumatol. 2004;14(2):179-83. doi: 10.1007/s10165-004-0288-3.

Authors

Mitsuteru Akahoshi¹, Goichi Yoshimoto, Hitoshi Nakashima, Katsuhisa Miyake, Yasushi Inoue, Yosuke Tanaka, Hiroshi Tsukamoto, Takahiko Horiuchi, Takeshi Otsuka, Mine Harada

Affiliation

¹ Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

PMID: 17143671
DOI: 10.1007/s10165-004-0288-3

Abstract

We describe a case of hypertrophic cranial pachymeningitis (HCP) associated with Wegener's granulomatosis (WG) in a 60-year-old man presenting with chronic headache and multiple cranial nerve neuropathies. A test for antibodies to the neutrophil cytoplasmic protein myeloperoxidase (MPO-ANCA) was positive in this case. We review the literature on perinuclear (p)-ANCA-related HCP, including our case. This case indicates the link between MPO-ANCA-positive WG and HCP.