Liver toxicity after treatment with gefitinib and anastrozole: drug-drug interactions through cytochrome p450?

J Clin Oncol. 2006 Dec 10;24(35):e60-1. doi: 10.1200/JCO.2006.07.8261.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Comment

MeSH terms

  • Anastrozole
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / pathology
  • Chemical and Drug Induced Liver Injury / enzymology*
  • Chemical and Drug Induced Liver Injury / etiology*
  • Cytochrome P-450 Enzyme System / metabolism*
  • Drug Interactions
  • Female
  • Gefitinib
  • Humans
  • Isoenzymes / metabolism
  • Lymphatic Metastasis
  • Middle Aged
  • Nitriles / administration & dosage
  • Nitriles / adverse effects
  • Quinazolines / administration & dosage
  • Quinazolines / adverse effects
  • Triazoles / administration & dosage
  • Triazoles / adverse effects

Substances

  • Isoenzymes
  • Nitriles
  • Quinazolines
  • Triazoles
  • Anastrozole
  • Cytochrome P-450 Enzyme System
  • Gefitinib