Abstract
The alternative sigma factor (RpoN-RpoS) pathway controls the expression of key virulence factors in Borrelia burgdorferi. However, evidence to support whether RpoN controls rpoS directly or, perhaps, indirectly via a transactivator has been lacking. Herein we provide biochemical and genetic evidence that RpoN directly controls rpoS in B. burgdorferi.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antigens, Bacterial / genetics
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Proteins / genetics*
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Base Sequence
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Binding Sites
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Borrelia burgdorferi / genetics*
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Gene Expression Regulation, Bacterial*
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Molecular Sequence Data
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Mutagenesis, Site-Directed
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Promoter Regions, Genetic
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RNA Polymerase Sigma 54 / physiology*
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Sigma Factor / genetics*
Substances
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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OspC protein
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Sigma Factor
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sigma factor KatF protein, Bacteria
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RNA Polymerase Sigma 54