Maintaining hematopoietic stem cells in the vascular niche

Mark J Kiel; Sean J Morrison

doi:10.1016/j.immuni.2006.11.005

Maintaining hematopoietic stem cells in the vascular niche

Immunity. 2006 Dec;25(6):862-4. doi: 10.1016/j.immuni.2006.11.005.

Authors

Mark J Kiel¹, Sean J Morrison

Affiliation

¹ Howard Hughes Medical Institute, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

PMID: 17174928
DOI: 10.1016/j.immuni.2006.11.005

Abstract

In this issue of Immunity, Sugiyama et al. (2006) provide evidence that most bone-marrow hematopoietic stem cells (HSCs) reside in vascular niches containing reticular cells that secrete CXCL12, a chemokine that promotes HSC maintenance.

Publication types

Comment
Review

MeSH terms

Animals
Bone Marrow / blood supply
Bone Marrow / ultrastructure*
Hematopoietic Stem Cells / cytology*
Hematopoietic System / cytology*
Humans
Osteoblasts / cytology