L-type voltage-gated calcium channels (LTCs) may control neuronal gene expression by increasing nuclear Ca(2+) levels or regulating Ca(2+)/calmodulin-dependent transcription factors. In the November 3 issue of Cell, Gomez-Ospina et al. demonstrate another signaling mechanism, in which a C-terminal fragment of LTC translocates to the nucleus in a calcium-dependent manner and directly regulates transcription.