Disseminated Mycobacterium tuberculosis infection due to interferon gamma deficiency. Response to replacement therapy

Thorax. 2007 Jan;62(1):97-9. doi: 10.1136/thx.2005.051649.

Abstract

The case of a previously healthy HIV seronegative woman with disseminated Mycobacterium tuberculosis infection and markedly reduced interferon gamma production is reported here. Complete healing of her disseminated lesions was seen only after addition of subcutaneous interferon gamma to her tuberculosis treatment.

Publication types

  • Case Reports

MeSH terms

  • Administration, Cutaneous
  • Female
  • HIV Seronegativity / immunology*
  • Humans
  • Interferon-gamma / administration & dosage
  • Interferon-gamma / deficiency*
  • Middle Aged
  • Mycobacterium tuberculosis / immunology*
  • Tuberculosis / drug therapy
  • Tuberculosis / immunology*

Substances

  • Interferon-gamma