Keeping the noise down in ES cells

Cell. 2006 Dec 29;127(7):1301-2. doi: 10.1016/j.cell.2006.12.011.

Abstract

A new report (Szutorisz et al., 2006) suggests that embryonic stem (ES) cells adopt an unusual strategy to remain perpetually poised for differentiation. Apparently, ES cells use the proteasome to target transcriptional preinitiation complexes, thus minimizing transcriptional noise at genes that promote differentiation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation
  • DNA, Intergenic / genetics
  • DNA, Intergenic / metabolism
  • Embryonic Stem Cells / physiology*
  • Mice
  • Models, Biological
  • Proteasome Endopeptidase Complex / genetics*
  • Proteasome Endopeptidase Complex / metabolism
  • Proteasome Endopeptidase Complex / physiology
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Transcription, Genetic*

Substances

  • DNA, Intergenic
  • Transcription Factors
  • Proteasome Endopeptidase Complex