Abstract
The first, to our knowledge, miniature dual-axes confocal microscope has been developed, with an outer diameter of 10 mm, for subsurface imaging of biological tissues with 5-7 microm resolution. Depth-resolved en face images are obtained at 30 frames per second, with a field of view of 800 x 100 microm, by employing a two-dimensional scanning microelectromechanical systems mirror. Reflectance and fluorescence images are obtained with a laser source at 785 nm, demonstrating the ability to perform real-time optical biopsy.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Computer Systems
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Electronics
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Equipment Design
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Equipment Failure Analysis
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Fiber Optic Technology / instrumentation*
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Image Enhancement / instrumentation*
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Mechanics
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Micromanipulation / instrumentation*
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Micromanipulation / methods
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Microscopy, Confocal / instrumentation*
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Microscopy, Confocal / methods
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Miniaturization
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Reproducibility of Results
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Sensitivity and Specificity
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Spectrophotometry, Infrared / instrumentation*
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Spectrophotometry, Infrared / methods
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Transducers