In vitro studies with DQ-113 and comparison fluoroquinolones to determine propensities to select resistance in gram-positive cocci

Seong Geun Hong; Ellen Smith Moland; Paul A Wickman; Jennifer A Black; Ashfaque Hossain; Nancy D Hanson; Kenneth S Thomson

doi:10.1128/AAC.00959-06

In vitro studies with DQ-113 and comparison fluoroquinolones to determine propensities to select resistance in gram-positive cocci

Antimicrob Agents Chemother. 2007 Apr;51(4):1512-4. doi: 10.1128/AAC.00959-06. Epub 2007 Jan 12.

Authors

Seong Geun Hong¹, Ellen Smith Moland, Paul A Wickman, Jennifer A Black, Ashfaque Hossain, Nancy D Hanson, Kenneth S Thomson

Affiliation

¹ Creighton University School of Medicine, Department of Medical Microbiology and Immunology, Center for Research in Anti-Infectives and Biotechnology, 2500 California Plaza, Omaha, NE 68178, USA.

Abstract

DQ-113 was compared in vitro to sitafloxacin, moxifloxacin, levofloxacin, and ciprofloxacin for potential to select mutational resistance in multiresistant staphylococci, pneumococci, and enterococci. Its ability to select less-susceptible mutants varied according to species, being lowest with staphylococci, intermediate with pneumococci, and greatest with enterococci.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Resistance, Bacterial*
Drug Resistance, Microbial / genetics
Fluoroquinolones / pharmacology*
Gram-Positive Bacterial Infections / microbiology
Gram-Positive Cocci / drug effects*
Gram-Positive Cocci / genetics
Gram-Positive Cocci / isolation & purification
Microbial Sensitivity Tests
Quinolones / chemistry*
Quinolones / pharmacology*

Substances

DQ113
Fluoroquinolones
Quinolones