Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome

Hiroaki Shibahara; Kumiko Kikuchi; Yuki Hirano; Tatsuya Suzuki; Satoru Takamizawa; Mitsuaki Suzuki

doi:10.1016/j.fertnstert.2006.11.021

Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome

Fertil Steril. 2007 Jun;87(6):1487-90. doi: 10.1016/j.fertnstert.2006.11.021. Epub 2007 Jan 24.

Authors

Hiroaki Shibahara¹, Kumiko Kikuchi, Yuki Hirano, Tatsuya Suzuki, Satoru Takamizawa, Mitsuaki Suzuki

Affiliation

¹ Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Tochigi, Japan. sibahara@jichi.ac.jp <sibahara@jichi.ac.jp>

PMID: 17254579
DOI: 10.1016/j.fertnstert.2006.11.021

Abstract

Metformin appears to be an effective medicine to induce ovulation in women with polycystic ovary syndrome and insulin resistance. After the introduction of metformin treatment for such cases, the use of gonadotropin in combination with metformin significantly increased the incidence of multiple pregnancies.

Publication types

Controlled Clinical Trial

MeSH terms

Adult
Drug Therapy, Combination
Female
Gonadotropins / therapeutic use*
Humans
Infertility, Female / complications*
Metformin / therapeutic use*
Polycystic Ovary Syndrome / complications*
Pregnancy
Pregnancy Rate
Pregnancy, Multiple / drug effects
Pregnancy, Multiple / statistics & numerical data*

Substances

Gonadotropins
Metformin