Abstract
Basic fibroblast growth factor (bFGF), a metastatic growth factor is known to be one of the promoting factors in the tumor induced angiogenesis. The antiangiogenic activity of acetyl 11-keto beta-boswellic acid was screened against bFGF-induced angiogenesis using in-vivo Matrigel Plug Assay. Histological & colorimetric examination confirmed that numerous blood vessels were present in Matrigel+bFGF group in comparison to Matrigel alone treated mice. Acetyl 11-keto beta-boswellic acids (10 mg/kg/d) inhibited the Matrigel+bFGF-induced angiogenesis significantly (P<0.01) in contrast to anti-inflammatory agent indomethacin (10 mg/kg/d) and alkylating agent cyclophosphamide (10 mg/kg/d).
MeSH terms
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Angiogenesis Inhibitors / pharmacology*
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Angiogenesis Inhibitors / therapeutic use
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Animals
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Antineoplastic Agents, Alkylating / pharmacology
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Collagen
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Cyclooxygenase Inhibitors / pharmacology
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Cyclophosphamide / pharmacology
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Disease Models, Animal
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Drug Combinations
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Fibroblast Growth Factor 2
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Indomethacin / pharmacology
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Laminin
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Male
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Mice
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Mice, Inbred C57BL
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Neovascularization, Pathologic / chemically induced
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Neovascularization, Pathologic / pathology
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Neovascularization, Pathologic / prevention & control*
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Proteoglycans
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Reproducibility of Results
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Subcutaneous Tissue / blood supply*
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Triterpenes / pharmacology*
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Triterpenes / therapeutic use
Substances
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Angiogenesis Inhibitors
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Antineoplastic Agents, Alkylating
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Cyclooxygenase Inhibitors
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Drug Combinations
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Laminin
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Proteoglycans
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Triterpenes
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acetyl-11-ketoboswellic acid
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Fibroblast Growth Factor 2
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matrigel
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Cyclophosphamide
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Collagen
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Indomethacin