Abstract
Phytochemical investigation of the whole plants of Wollastonia biflora led to the isolation and identification of three new germacrane-type sesquiterpenes (1-3), two new pimarane-type diterpenes (4, 5), and a new naphthalene glycoside (6), along with 11 known compounds. Their structures were characterized on the basis of spectroscopic analyses and chemical methods. Compounds 1, 2, and 3 showed significant cytotoxic activity against the growth of hepatocellular carcinoma BEL-7402 cells in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abietanes / chemistry
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Abietanes / isolation & purification*
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Abietanes / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Asteraceae / chemistry*
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Humans
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Molecular Structure
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Naphthalenes / chemistry
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Naphthalenes / isolation & purification*
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Naphthalenes / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Sesquiterpenes, Germacrane / chemistry
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Sesquiterpenes, Germacrane / isolation & purification*
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Sesquiterpenes, Germacrane / pharmacology
Substances
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Abietanes
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Naphthalenes
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Sesquiterpenes, Germacrane
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pimarane