New types of MYST3-CBP and CBP-MYST3 fusion transcripts in t(8;16)(p11;p13) acute myeloid leukemias

Haematologica. 2007 Feb;92(2):262-3. doi: 10.3324/haematol.10744.

Abstract

The t(8;16)(p11;p13) translocation, associated with poor prognosis acute monocytic leukemia, fuses MYST3 on chromosome region 8p11 to CBP on chromosome region 16p13. Two types of MYST3-CBP and CBP-MYST3 fusion transcripts have been identified in patients. We describe two new types of MYST3-CBP transcripts and a new primer set.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Carrier Proteins / genetics*
  • Chromosomes, Human, Pair 16*
  • Chromosomes, Human, Pair 8*
  • Corticosterone
  • DNA Primers / chemistry
  • Female
  • Histone Acetyltransferases / genetics*
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Middle Aged
  • Oncogene Proteins, Fusion / biosynthesis
  • Oncogene Proteins, Fusion / genetics*
  • Prognosis
  • Reverse Transcriptase Polymerase Chain Reaction / methods*
  • Translocation, Genetic*

Substances

  • Carrier Proteins
  • DNA Primers
  • Oncogene Proteins, Fusion
  • Histone Acetyltransferases
  • KAT6A protein, human
  • Corticosterone