Monitoring serum free light chains in patients with multiple myeloma who achieved negative immunofixation after allogeneic stem cell transplantation

Haematologica. 2007 Feb;92(2):275-6. doi: 10.3324/haematol.10568.

Abstract

Monitoring of serum free immunoglobulin light chains (FLC) in 26 myeloma patients who achieved immunofixation negativity after allografting showed a decrease of FLC at a median of 128 days before immunofixation negativity. In patients who subsequently relapsed, a 25% increase of FLC was observed at a median of 98 days before immunofixation positivity.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Binding Sites
  • Biomarkers, Tumor / blood
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoglobulin Light Chains / blood*
  • Male
  • Middle Aged
  • Multiple Myeloma / blood*
  • Multiple Myeloma / therapy*
  • Remission Induction
  • Stem Cell Transplantation / methods*
  • Time Factors
  • Treatment Outcome

Substances

  • Biomarkers, Tumor
  • Immunoglobulin Light Chains