Mechanisms of action of statins in stroke

Expert Opin Ther Targets. 2007 Mar;11(3):273-8. doi: 10.1517/14728222.11.3.273.

Abstract

Statins decrease the incidence of cardiovascular events and death in patients with coronary artery disease. Moreover, the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) study has recently demonstrated that high-dose atorvastatin may also reduce the recurrence of stroke in patients with previous stroke or transitory ischemic attack.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carotid Artery Diseases / drug therapy
  • Clinical Trials as Topic
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Stroke / drug therapy*
  • Thrombosis / drug therapy

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors