Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours

Br J Cancer. 2007 Mar 12;96(5):776-82. doi: 10.1038/sj.bjc.6603551. Epub 2007 Feb 13.

Abstract

A tissue microarray analysis of 22 proteins in gastrointestinal stromal tumours (GIST), followed by an unsupervised, hierarchical monothetic cluster statistical analysis of the results, allowed us to detect a vascular endothelial growth factor (VEGF) protein overexpression signature discriminator of prognosis in GIST, and discover novel VEGF-A DNA variants that may have functional significance.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Base Sequence
  • Chromatography, High Pressure Liquid
  • Cluster Analysis
  • DNA Mutational Analysis
  • DNA Primers
  • Gastrointestinal Stromal Tumors / genetics
  • Gastrointestinal Stromal Tumors / metabolism*
  • Gastrointestinal Stromal Tumors / pathology*
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Molecular Sequence Data
  • Mutation
  • Polymerase Chain Reaction
  • Prognosis
  • Protein Array Analysis
  • Tissue Array Analysis
  • Vascular Endothelial Growth Factor A / biosynthesis*
  • Vascular Endothelial Growth Factor A / genetics*

Substances

  • DNA Primers
  • Vascular Endothelial Growth Factor A