Abstract
The connection of two active molecules across an easily released bridge as a new type of potentially active molecule has been studied. The synthesis is based on derivatives that originate from isonicotinoyl hydrazide, pyrazinamide, p-aminosalicylic acid (PAS), ethambutol, and ciprofloxacin. The lipophilicity, hydrolysis (stability of the compounds), and antituberculotic activity as well as the structure-lipophilicity and structure-activity relationships are discussed.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / chemical synthesis
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Antitubercular Agents / chemistry*
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Antitubercular Agents / pharmacology*
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, High Pressure Liquid
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Half-Life
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Isoniazid / chemical synthesis
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Isoniazid / pharmacology
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Kinetics
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Lipids / chemistry
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Microbial Sensitivity Tests
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Mycobacterium avium / drug effects
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Mycobacterium kansasii / drug effects
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Pyrazinamide / chemical synthesis
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Pyrazinamide / pharmacology
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Quantitative Structure-Activity Relationship
Substances
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Antitubercular Agents
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Lipids
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Pyrazinamide
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Isoniazid