Asymmetric synthesis of novel alpha-amino acids with beta-branched side chains

Bioorg Med Chem Lett. 2007 May 1;17(9):2401-3. doi: 10.1016/j.bmcl.2007.02.041. Epub 2007 Feb 17.

Abstract

An asymmetric synthesis of alpha-amino acids with novel beta-branched side chains has been implemented. The syntheses feature a p-toluenesulfinylimine induced chiral Strecker approach and were found to be applicable to the introduction of both aliphatic and aromatic beta-branched sidechains for preparation of previously unknown alpha-amino acids.

MeSH terms

  • Amino Acids / chemical synthesis*
  • Amino Acids / chemistry*
  • Chemistry, Organic / methods
  • Chemistry, Pharmaceutical / methods*
  • Drug Design
  • Models, Chemical
  • Molecular Conformation

Substances

  • Amino Acids