Anti-muscarinic autoantibodies and vagal modulation in Chagas disease: positive allosteric modulators vs desensitization and downregulation of M2 cardiac acetylcholine receptors

Int J Cardiol. 2008 Jan 24;123(3):328-9; author reply 330-2. doi: 10.1016/j.ijcard.2006.11.176. Epub 2007 Mar 1.
No abstract available

Publication types

  • Comment
  • Comparative Study
  • Letter

MeSH terms

  • Allosteric Regulation
  • Autoantibodies / blood
  • Autoantibodies / immunology*
  • Autonomic Nervous System / immunology
  • Autonomic Nervous System / physiology
  • Biomarkers / blood
  • Chagas Disease / diagnosis
  • Chagas Disease / immunology*
  • Down-Regulation
  • Female
  • Heart Rate / immunology*
  • Humans
  • Immunization
  • Male
  • Prognosis
  • Receptors, Cholinergic / immunology
  • Receptors, Cholinergic / metabolism*
  • Receptors, Muscarinic / immunology
  • Receptors, Muscarinic / metabolism*
  • Sensitivity and Specificity

Substances

  • Autoantibodies
  • Biomarkers
  • Receptors, Cholinergic
  • Receptors, Muscarinic