Steroid treatment in children with sickle-cell disease

Haematologica. 2007 Mar;92(3):425-6. doi: 10.3324/haematol.10800.

Abstract

Given the controversy concerning the effects of steroids in patients with sickle cell disease (SCD), we evaluated the tolerability of long-term steroid treatment in 16 children with SCD and autoimmune and/or systemic diseases. The steroid treatment was poorly tolerated.

Publication types

  • Letter
  • Multicenter Study

MeSH terms

  • Adolescent
  • Anemia, Sickle Cell / complications*
  • Anemia, Sickle Cell / drug therapy
  • Anemia, Sickle Cell / therapy
  • Arthritis / complications
  • Arthritis / drug therapy
  • Autoimmune Diseases / complications
  • Autoimmune Diseases / drug therapy*
  • Blood Transfusion
  • Child
  • Child, Preschool
  • Combined Modality Therapy
  • Disease Susceptibility
  • Drug Evaluation
  • Exchange Transfusion, Whole Blood
  • Female
  • Follow-Up Studies
  • Humans
  • Hydroxyurea / therapeutic use
  • Immunosuppressive Agents / adverse effects*
  • Immunosuppressive Agents / therapeutic use
  • Infant
  • Infarction / etiology
  • Infections / etiology
  • Kidney / blood supply
  • Leukocyte Count
  • Male
  • Pain / etiology
  • Prednisone / adverse effects*
  • Prednisone / therapeutic use
  • Retrospective Studies
  • Sarcoidosis / complications
  • Sarcoidosis / drug therapy
  • Stroke / etiology
  • Treatment Outcome
  • Vascular Diseases / etiology
  • Vascular Diseases / prevention & control

Substances

  • Immunosuppressive Agents
  • Prednisone
  • Hydroxyurea