Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable lewis carcinoma

Bull Exp Biol Med. 2006 Jul;142(1):69-72. doi: 10.1007/s10517-006-0294-x.
[Article in English, Russian]

Abstract

We studied the effects of four synthetic amides of betulonic acid containing amino acid fragments (d,l-alpha-alanine, beta-alanine, and their methyl esters) on the rate of growth and metastatic dissemination of transplantable Lewis lung carcinoma in C57Bl/6 mice. The test compounds were administered intragastrically in a single dose of 500 mg/kg. 3-[-oxo-20(29)-lupen-28-oilamino]-propionic acid suppressed primary tumor growth (by 26%) and decreased the number of lung metastases (by more than 2 times). Antitumor and antimetastatic activity of triterpenoids decreased after methylation of the amino acid fragment in betulonic acid.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine / chemistry
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / therapeutic use*
  • Carcinoma, Lewis Lung / drug therapy*
  • Carcinoma, Lewis Lung / pathology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Neoplasm Metastasis / pathology
  • Neoplasm Metastasis / prevention & control*
  • Oleanolic Acid / analogs & derivatives*
  • Oleanolic Acid / chemistry
  • Oleanolic Acid / therapeutic use

Substances

  • (3-oxo-20(29)-lupene-28-oyl)-3-aminopropionamide
  • Antineoplastic Agents
  • Oleanolic Acid
  • Alanine