Participation of mesenchymal precursor cells in wound healing on skin flap model

E D Goldberg; A M Dygai; V V Zhdanov; G N Zyuz'kov; L A Gur'yantseva; O V Pershina; T N Povet'eva; L A Stavrova; T Yu Khrichkova

doi:10.1007/s10517-006-0307-9

Participation of mesenchymal precursor cells in wound healing on skin flap model

Bull Exp Biol Med. 2006 Jul;142(1):116-8. doi: 10.1007/s10517-006-0307-9.

[Article in English, Russian]

Authors

E D Goldberg¹, A M Dygai, V V Zhdanov, G N Zyuz'kov, L A Gur'yantseva, O V Pershina, T N Povet'eva, L A Stavrova, T Yu Khrichkova

Affiliation

¹ Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.

PMID: 17369919
DOI: 10.1007/s10517-006-0307-9

Abstract

We studied the state of different pools of mesenchymal precursor cells in the bone marrow, peripheral blood, and wound surface after modeling of tissue damage by skin flap removal. The participation of regional and circulating stromal precursors in the healing of skin defect and the absence of compensatory reaction of the regeneratory process deep reserve, mesenchymal stem cells of the bone marrow, was demonstrated.

Publication types

Comparative Study

MeSH terms

Animals
Bone Marrow Cells / cytology
Bone Marrow Cells / physiology*
Cells, Cultured
Colony-Forming Units Assay
Female
Insulin
Intercellular Signaling Peptides and Proteins
Male
Mesenchymal Stem Cells / physiology*
Mice
Mice, Inbred CBA
Skin / injuries*
Statistics, Nonparametric
Stromal Cells / cytology
Stromal Cells / physiology
Wound Healing / physiology*

Substances

Insulin
Intercellular Signaling Peptides and Proteins