Etiological heterogeneity in the development of antisocial behavior: the Virginia Twin Study of Adolescent Behavioral Development and the Young Adult Follow-Up

Psychol Med. 2007 Aug;37(8):1193-202. doi: 10.1017/S0033291707000293. Epub 2007 Mar 22.

Abstract

Background: Longitudinal, genetically informed, prospective data collected on a large population of male twins (n=1037) were used to examine developmental differences in the etiology of antisocial behavior.

Method: Analyses were carried out on both mother- and child-reported symptoms of conduct disorder (CD) in 10- to 17-year-old twins from the Virginia Twin Study of Adolescent Behavioral Development (VTSABD) and self-reported antisocial behavior by the twins as young adults from the Young Adult Follow-Up (YAFU) study.

Results: The following trends were identified: (1) a single genetic factor influencing antisocial behavior beginning at age 10 through young adulthood ('life-course persistent'); (2) a shared-environmental effect beginning in adolescence ('adolescent-onset'); (3) a transient genetic effect at puberty; and (4) a genetic influence specific to adult antisocial behavior.

Conclusions: Overall, these etiological findings are consistent with predictions from Moffitt's developmental theory of antisocial behavior. The genetic effect at puberty at ages 12-15 is also consistent with a genetically mediated influence on the timing of puberty affecting the expression of genetic differences in antisocial outcomes.

Publication types

  • Research Support, N.I.H., Extramural
  • Twin Study

MeSH terms

  • Adolescent
  • Adult
  • Antisocial Personality Disorder / genetics*
  • Antisocial Personality Disorder / psychology
  • Child
  • Conduct Disorder / genetics*
  • Conduct Disorder / psychology
  • Diseases in Twins / genetics*
  • Diseases in Twins / psychology
  • Female
  • Gene Expression / physiology
  • Humans
  • Longitudinal Studies
  • Male
  • Personality Assessment
  • Phenotype
  • Prospective Studies
  • Puberty
  • Social Environment
  • Twins, Dizygotic / genetics
  • Twins, Dizygotic / psychology
  • Twins, Monozygotic / genetics
  • Twins, Monozygotic / psychology
  • Virginia