Adhesion of Staphylococcus saprophyticus to renal tubular epithelial cells is mediated by an N-acetyl-galactosamine-specific structure

Zentralbl Bakteriol. 1991 Aug;275(3):358-63. doi: 10.1016/s0934-8840(11)80300-2.

Abstract

S. saprophyticus CCM883 and 9325 were found to adhere to the tubular cell line LLC-PK1. An ELISA technique was used to determine adherence of bacteria and inhibition of adherence by various carbohydrates. Only N-acetyl-galactosamine was found to significantly inhibit adhesion (p less than 0.001), which suggests that the surface component mediating adhesion recognizes structures on the target cell that contain this carbohydrate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylgalactosamine / pharmacology*
  • Animals
  • Bacterial Adhesion / drug effects*
  • Cell Line
  • Enzyme-Linked Immunosorbent Assay
  • Epithelial Cells
  • Epithelium / microbiology
  • Kidney Tubules / cytology
  • Kidney Tubules / microbiology*
  • Staphylococcus / drug effects
  • Staphylococcus / metabolism*

Substances

  • Acetylgalactosamine