Abstract
Murine polyomavirus and simian virus 40 were used to evaluate the potencies of the compounds of three classes of acyclic nucleoside phosphonates: (i) the original HPMP (3-hydroxy-2-phosphonomethoxypropyl) and PME (2-phosphonomethoxyethyl) derivatives, (ii) the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidine (DAPy) derivatives, and (iii) a new class of HPMP derivatives containing a 5-azacytosine moiety. The last class showed the highest activities and selectivities against both polyomaviruses.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiviral Agents / chemistry
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Antiviral Agents / classification
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Antiviral Agents / pharmacology*
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Antiviral Agents / toxicity
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Cell Line
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Cidofovir
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Cytosine / analogs & derivatives
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Cytosine / pharmacology
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Cytosine / toxicity
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Mice
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Microbial Sensitivity Tests
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Nucleosides / chemistry
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Nucleosides / classification
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Nucleosides / pharmacology*
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Nucleosides / toxicity
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Organophosphonates / chemistry
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Organophosphonates / classification
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Organophosphonates / pharmacology*
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Organophosphonates / toxicity
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Polyomavirus / drug effects*
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Pyrimidine Nucleosides / chemistry
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Pyrimidine Nucleosides / pharmacology
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Pyrimidine Nucleosides / toxicity
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Pyrimidines / chemistry
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Pyrimidines / pharmacology
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Pyrimidines / toxicity
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Simian virus 40 / drug effects*
Substances
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Antiviral Agents
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Nucleosides
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Organophosphonates
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Pyrimidine Nucleosides
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Pyrimidines
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2,4-diaminopyrimidine
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Cytosine
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Cidofovir