Abstract
Gastroesophageal reflux disease and other related symptoms are common comorbidities for HIV-infected patients. Therefore, concurrent use of proton pump inhibitors and antiretrovirals is a common practice in the clinical setting. However, this practice may alter antiretroviral pharmacokinetics and lead to treatment failure due to inadequate drug exposure. Clinician awareness of these complex interactions is essential for optimal HIV management. This review summarizes the current knowledge on the interactions between proton pump inhibitors and antiretrovirals, and makes recommendations for the coadministration of proton pump inhibitors.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Retroviral Agents / adverse effects
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Anti-Retroviral Agents / pharmacokinetics
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Anti-Retroviral Agents / therapeutic use*
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Anti-Ulcer Agents / adverse effects
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Anti-Ulcer Agents / pharmacokinetics
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Anti-Ulcer Agents / therapeutic use*
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Drug Interactions*
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Drug Therapy, Combination
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Gastroesophageal Reflux / complications
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Gastroesophageal Reflux / drug therapy
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Gastroesophageal Reflux / metabolism
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HIV Infections / complications
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HIV Infections / drug therapy
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HIV Infections / metabolism
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Humans
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Proton Pump Inhibitors*
Substances
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Anti-Retroviral Agents
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Anti-Ulcer Agents
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Proton Pump Inhibitors