Ultrasensitive p24 antigen assay for diagnosis of perinatal human immunodeficiency virus type 1 infection

J Clin Microbiol. 2007 Jul;45(7):2274-7. doi: 10.1128/JCM.00813-07. Epub 2007 May 2.

Abstract

We evaluated an ultrasensitive p24 antigen enzyme immunosorbent assay on 802 plasma specimens from 582 infants and children of 0 to 180 days of age. Overall sensitivity and specificity were 91.7% and 98.5%, respectively. After exclusion of infants of less than 7 days of age, the sensitivity and specificity were 93.7% and 98.3%, respectively.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Enzyme-Linked Immunosorbent Assay / methods*
  • HIV Core Protein p24 / analysis*
  • HIV Core Protein p24 / blood*
  • HIV Infections / diagnosis*
  • HIV Infections / epidemiology
  • HIV-1
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Newborn, Diseases / diagnosis*
  • Infant, Newborn, Diseases / epidemiology
  • Sensitivity and Specificity
  • United States

Substances

  • HIV Core Protein p24