Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists

Rui Zhang; Aihua Wang; Alan DeAngelis; Patricia Pelton; Jun Xu; Peifang Zhu; Lubing Zhou; Keith Demarest; William V Murray; Gee-Hong Kuo

doi:10.1016/j.bmcl.2007.05.007

Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists

Bioorg Med Chem Lett. 2007 Jul 15;17(14):3855-9. doi: 10.1016/j.bmcl.2007.05.007. Epub 2007 May 10.

Authors

Rui Zhang¹, Aihua Wang, Alan DeAngelis, Patricia Pelton, Jun Xu, Peifang Zhu, Lubing Zhou, Keith Demarest, William V Murray, Gee-Hong Kuo

Affiliation

¹ Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, LLC, 8 Clarke Drive, Cranbury, NJ 08512, USA. rzhang4@prdus.jnj.com

PMID: 17524639
DOI: 10.1016/j.bmcl.2007.05.007

Abstract

A novel series of potent and selective PPARdelta agonists, para-alkylthiophenoxyacetic acids, was identified. The synthesis and structure-activity relationships are described.

MeSH terms

Area Under Curve
Glycolates / chemistry
Glycolates / pharmacokinetics
Glycolates / pharmacology*
PPAR delta / agonists*
Structure-Activity Relationship

Substances

Glycolates
PPAR delta
thiophenoxyacetic acid