Abstract
Novel, potent small molecule motilin receptor antagonists are described. These peptidomimetic macrocycles are composed of a tripeptide cyclized backbone-to-backbone with a nonpeptidic tether and bear new unnatural amino acids containing basic side chains.
MeSH terms
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Amino Acids / chemistry*
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Cyclization
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Macrocyclic Compounds / pharmacology*
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Receptors, Gastrointestinal Hormone / antagonists & inhibitors*
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Receptors, Gastrointestinal Hormone / chemistry
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Receptors, Neuropeptide / antagonists & inhibitors*
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Receptors, Neuropeptide / chemistry
Substances
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Amino Acids
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Macrocyclic Compounds
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Receptors, Gastrointestinal Hormone
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Receptors, Neuropeptide
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motilin receptor